Cost for physician-diagnosed influenza and influenza-like illnesses on primary care level in Germany--results of a database analysis from May 2010 to April 2012.
Identifieur interne : 000141 ( Main/Exploration ); précédent : 000140; suivant : 000142Cost for physician-diagnosed influenza and influenza-like illnesses on primary care level in Germany--results of a database analysis from May 2010 to April 2012.
Auteurs : Birgit Ehlken [Allemagne] ; Anastassia Anastassopoulou [Allemagne] ; Johannes Hain [Allemagne] ; Claudia Schröder [Allemagne] ; Klaus Wahle [Allemagne]Source :
- BMC public health [ 1471-2458 ] ; 2015.
Descripteurs français
- KwdFr :
- Absentéisme (MeSH), Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Allemagne (épidémiologie), Bases de données factuelles (statistiques et données numériques), Classification internationale des maladies (MeSH), Coûts indirects de la maladie (MeSH), Dépenses de santé (statistiques et données numériques), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Facteurs de risque (MeSH), Femelle (MeSH), Grippe humaine (complications), Grippe humaine (économie), Humains (MeSH), Mâle (MeSH), Pédiatrie (statistiques et données numériques), Services de santé (statistiques et données numériques), Services de santé (économie), Soins de santé primaires (statistiques et données numériques), Études rétrospectives (MeSH).
- MESH :
- statistiques et données numériques : Bases de données factuelles, Dépenses de santé, Pédiatrie, Services de santé, Soins de santé primaires.
- économie : Grippe humaine, Services de santé.
- épidémiologie : Allemagne.
- complications : Absentéisme, Adolescent, Adulte, Adulte d'âge moyen, Classification internationale des maladies, Coûts indirects de la maladie, Enfant, Enfant d'âge préscolaire, Facteurs de risque, Femelle, Grippe humaine, Humains, Mâle, Études rétrospectives.
English descriptors
- KwdEn :
- Absenteeism (MeSH), Adolescent (MeSH), Adult (MeSH), Child (MeSH), Child, Preschool (MeSH), Cost of Illness (MeSH), Databases, Factual (statistics & numerical data), Female (MeSH), Germany (epidemiology), Health Expenditures (statistics & numerical data), Health Services (economics), Health Services (statistics & numerical data), Humans (MeSH), Influenza, Human (complications), Influenza, Human (economics), International Classification of Diseases (MeSH), Male (MeSH), Middle Aged (MeSH), Pediatrics (statistics & numerical data), Primary Health Care (statistics & numerical data), Retrospective Studies (MeSH), Risk Factors (MeSH).
- MESH :
- complications : Influenza, Human.
- economics : Health Services, Influenza, Human.
- epidemiology : Germany.
- statistics & numerical data : Databases, Factual, Health Expenditures, Health Services, Pediatrics, Primary Health Care.
- Absenteeism, Adolescent, Adult, Child, Child, Preschool, Cost of Illness, Female, Humans, International Classification of Diseases, Male, Middle Aged, Retrospective Studies, Risk Factors.
Abstract
BACKGROUND
Seasonal influenza is one of the most significant infectious diseases in Germany; epidemic outbreaks occur every winter and cause substantial morbidity and mortality. However, published data from Germany on the current economic burden of influenza and the costs per episode are lacking.
METHODS
A retrospective database analysis was conducted using a longitudinal electronic medical records database (IMS Disease Analyzer). Patients with influenza, diagnosed by German office-based physicians using ICD-10 J09-11 (International Classification of Diseases, 10(th) revision), who were observable in the database from 12 months before the index (diagnosis) date until 1 month afterwards, were included. The selection window, defined to cover two influenza seasons, was May 2010 to April 2012. Direct and indirect costs were evaluated from payer, patient and societal perspectives. Published unit costs and tariffs from Germany (2012) were used for the analysis.
RESULTS
A total of 21,039 influenza-attributable episodes in 17,836 adults, managed by primary care physicians (PCP) and 7,107 episodes in 6,288 children, managed by pediatricians, were eligible for analysis. The mean (±Standard Deviation (SD)) age of the adults with at least one episode was 46 (±18) years and 7 (±4) years in the children. The presence of clinical risk factors was documented for 39% episodes in adults and 24% episodes in children, with the most common being cardiovascular diseases in adults (29%) and chronic respiratory diseases in children (23%). Complications and severe symptoms accompanied the influenza-attributable episode (adults: 37%, children: 54%), bronchitis (adults: 16%, children: 19%) and acute upper respiratory infection (adults: 15%, children: 21%) being the most frequent. From a societal perspective, the total average mean cost (±SD) per episode was €514 (±609) in adults, where work days lost were the main cost driver (82%), and €105 (±224) in children. Complications and severe symptoms increased the cost per episode versus episodes without by 1.7 times in adults (€684 (±713) vs. €413 (±510)) and nearly 3 times in children (€149 (±278) vs. €55 (±116)).
CONCLUSIONS
Based on a large patient sample derived from representative PCP and pediatricians panels, our results demonstrate that seasonal influenza is associated with substantial clinical and economic burden in Germany.
DOI: 10.1186/s12889-015-1885-0
PubMed: 26093501
PubMed Central: PMC4475612
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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BEhlken@de.imshealth.com.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>IMS Health, Erika-Mann-Str. 5, 80636, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Anastassopoulou, Anastassia" sort="Anastassopoulou, Anastassia" uniqKey="Anastassopoulou A" first="Anastassia" last="Anastassopoulou">Anastassia Anastassopoulou</name><affiliation wicri:level="3"><nlm:affiliation>GlaxoSmithKline GmbH & Co. KG, Prinzregentenplatz 9, 81675, Munich, Germany. anastassia.a.anastassopoulou@gsk.com.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>GlaxoSmithKline GmbH & Co. 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KG, Prinzregentenplatz 9, 81675, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Schroder, Claudia" sort="Schroder, Claudia" uniqKey="Schroder C" first="Claudia" last="Schröder">Claudia Schröder</name><affiliation wicri:level="3"><nlm:affiliation>IMS Health, Erika-Mann-Str. 5, 80636, Munich, Germany. cuso@novonordisk.com.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>IMS Health, Erika-Mann-Str. 5, 80636, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Present Address: Novo Nordisk Pharma GmbH, Brucknerstr. 1, 55127, Mainz, Germany. cuso@novonordisk.com.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Present Address: Novo Nordisk Pharma GmbH, Brucknerstr. 1, 55127, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Wahle, Klaus" sort="Wahle, Klaus" uniqKey="Wahle K" first="Klaus" last="Wahle">Klaus Wahle</name><affiliation wicri:level="1"><nlm:affiliation>Department of General Medicine, University of Muenster, Domagkstr. 3, 48129, Muenster, Germany. klaus.wahle@praxiswb.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of General Medicine, University of Muenster, Domagkstr. 3, 48129, Muenster</wicri:regionArea><wicri:noRegion>48129, Muenster</wicri:noRegion><wicri:noRegion>48129, Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC public health</title><idno type="eISSN">1471-2458</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Absenteeism (MeSH)</term><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Child (MeSH)</term><term>Child, Preschool (MeSH)</term><term>Cost of Illness (MeSH)</term><term>Databases, Factual (statistics & numerical data)</term><term>Female (MeSH)</term><term>Germany (epidemiology)</term><term>Health Expenditures (statistics & numerical data)</term><term>Health Services (economics)</term><term>Health Services (statistics & numerical data)</term><term>Humans (MeSH)</term><term>Influenza, Human (complications)</term><term>Influenza, Human (economics)</term><term>International Classification of Diseases (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pediatrics (statistics & numerical data)</term><term>Primary Health Care (statistics & numerical data)</term><term>Retrospective Studies (MeSH)</term><term>Risk Factors (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Absentéisme (MeSH)</term><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Allemagne (épidémiologie)</term><term>Bases de données factuelles (statistiques et données numériques)</term><term>Classification internationale des maladies (MeSH)</term><term>Coûts indirects de la maladie (MeSH)</term><term>Dépenses de santé (statistiques et données numériques)</term><term>Enfant (MeSH)</term><term>Enfant d'âge préscolaire (MeSH)</term><term>Facteurs de risque (MeSH)</term><term>Femelle (MeSH)</term><term>Grippe humaine (complications)</term><term>Grippe humaine (économie)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Pédiatrie (statistiques et données numériques)</term><term>Services de santé (statistiques et données numériques)</term><term>Services de santé (économie)</term><term>Soins de santé primaires (statistiques et données numériques)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="economics" xml:lang="en"><term>Health Services</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Germany</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Databases, Factual</term><term>Health Expenditures</term><term>Health Services</term><term>Pediatrics</term><term>Primary Health Care</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Bases de données factuelles</term><term>Dépenses de santé</term><term>Pédiatrie</term><term>Services de santé</term><term>Soins de santé primaires</term></keywords><keywords scheme="MESH" qualifier="économie" xml:lang="fr"><term>Grippe humaine</term><term>Services de santé</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Allemagne</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Absenteeism</term><term>Adolescent</term><term>Adult</term><term>Child</term><term>Child, Preschool</term><term>Cost of Illness</term><term>Female</term><term>Humans</term><term>International Classification of Diseases</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term><term>Risk Factors</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="fr"><term>Absentéisme</term><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Classification internationale des maladies</term><term>Coûts indirects de la maladie</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de risque</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Mâle</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Seasonal influenza is one of the most significant infectious diseases in Germany; epidemic outbreaks occur every winter and cause substantial morbidity and mortality. However, published data from Germany on the current economic burden of influenza and the costs per episode are lacking.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>A retrospective database analysis was conducted using a longitudinal electronic medical records database (IMS Disease Analyzer). Patients with influenza, diagnosed by German office-based physicians using ICD-10 J09-11 (International Classification of Diseases, 10(th) revision), who were observable in the database from 12 months before the index (diagnosis) date until 1 month afterwards, were included. The selection window, defined to cover two influenza seasons, was May 2010 to April 2012. Direct and indirect costs were evaluated from payer, patient and societal perspectives. Published unit costs and tariffs from Germany (2012) were used for the analysis.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>A total of 21,039 influenza-attributable episodes in 17,836 adults, managed by primary care physicians (PCP) and 7,107 episodes in 6,288 children, managed by pediatricians, were eligible for analysis. The mean (±Standard Deviation (SD)) age of the adults with at least one episode was 46 (±18) years and 7 (±4) years in the children. The presence of clinical risk factors was documented for 39% episodes in adults and 24% episodes in children, with the most common being cardiovascular diseases in adults (29%) and chronic respiratory diseases in children (23%). Complications and severe symptoms accompanied the influenza-attributable episode (adults: 37%, children: 54%), bronchitis (adults: 16%, children: 19%) and acute upper respiratory infection (adults: 15%, children: 21%) being the most frequent. From a societal perspective, the total average mean cost (±SD) per episode was €514 (±609) in adults, where work days lost were the main cost driver (82%), and €105 (±224) in children. Complications and severe symptoms increased the cost per episode versus episodes without by 1.7 times in adults (€684 (±713) vs. €413 (±510)) and nearly 3 times in children (€149 (±278) vs. €55 (±116)).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Based on a large patient sample derived from representative PCP and pediatricians panels, our results demonstrate that seasonal influenza is associated with substantial clinical and economic burden in Germany.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">26093501</PMID><DateCompleted><Year>2015</Year><Month>12</Month><Day>23</Day></DateCompleted><DateRevised><Year>2019</Year><Month>03</Month><Day>18</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2458</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><PubDate><Year>2015</Year><Month>Jun</Month><Day>21</Day></PubDate></JournalIssue><Title>BMC public health</Title><ISOAbbreviation>BMC Public Health</ISOAbbreviation></Journal><ArticleTitle>Cost for physician-diagnosed influenza and influenza-like illnesses on primary care level in Germany--results of a database analysis from May 2010 to April 2012.</ArticleTitle><Pagination><MedlinePgn>578</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12889-015-1885-0</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Seasonal influenza is one of the most significant infectious diseases in Germany; epidemic outbreaks occur every winter and cause substantial morbidity and mortality. However, published data from Germany on the current economic burden of influenza and the costs per episode are lacking.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A retrospective database analysis was conducted using a longitudinal electronic medical records database (IMS Disease Analyzer). Patients with influenza, diagnosed by German office-based physicians using ICD-10 J09-11 (International Classification of Diseases, 10(th) revision), who were observable in the database from 12 months before the index (diagnosis) date until 1 month afterwards, were included. The selection window, defined to cover two influenza seasons, was May 2010 to April 2012. Direct and indirect costs were evaluated from payer, patient and societal perspectives. Published unit costs and tariffs from Germany (2012) were used for the analysis.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 21,039 influenza-attributable episodes in 17,836 adults, managed by primary care physicians (PCP) and 7,107 episodes in 6,288 children, managed by pediatricians, were eligible for analysis. The mean (±Standard Deviation (SD)) age of the adults with at least one episode was 46 (±18) years and 7 (±4) years in the children. The presence of clinical risk factors was documented for 39% episodes in adults and 24% episodes in children, with the most common being cardiovascular diseases in adults (29%) and chronic respiratory diseases in children (23%). Complications and severe symptoms accompanied the influenza-attributable episode (adults: 37%, children: 54%), bronchitis (adults: 16%, children: 19%) and acute upper respiratory infection (adults: 15%, children: 21%) being the most frequent. From a societal perspective, the total average mean cost (±SD) per episode was €514 (±609) in adults, where work days lost were the main cost driver (82%), and €105 (±224) in children. Complications and severe symptoms increased the cost per episode versus episodes without by 1.7 times in adults (€684 (±713) vs. €413 (±510)) and nearly 3 times in children (€149 (±278) vs. €55 (±116)).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Based on a large patient sample derived from representative PCP and pediatricians panels, our results demonstrate that seasonal influenza is associated with substantial clinical and economic burden in Germany.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ehlken</LastName><ForeName>Birgit</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>IMS Health, Erika-Mann-Str. 5, 80636, Munich, Germany. BEhlken@de.imshealth.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anastassopoulou</LastName><ForeName>Anastassia</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>GlaxoSmithKline GmbH & Co. KG, Prinzregentenplatz 9, 81675, Munich, Germany. anastassia.a.anastassopoulou@gsk.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hain</LastName><ForeName>Johannes</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>GlaxoSmithKline GmbH & Co. KG, Prinzregentenplatz 9, 81675, Munich, Germany. johannes.j.hain@gsk.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schröder</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>IMS Health, Erika-Mann-Str. 5, 80636, Munich, Germany. cuso@novonordisk.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Present Address: Novo Nordisk Pharma GmbH, Brucknerstr. 1, 55127, Mainz, Germany. cuso@novonordisk.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wahle</LastName><ForeName>Klaus</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of General Medicine, University of Muenster, Domagkstr. 3, 48129, Muenster, Germany. klaus.wahle@praxiswb.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>06</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Public Health</MedlineTA><NlmUniqueID>100968562</NlmUniqueID><ISSNLinking>1471-2458</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000041" MajorTopicYN="N">Absenteeism</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017281" MajorTopicYN="N">Cost of 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Anastassopoulou</name><name sortKey="Hain, Johannes" sort="Hain, Johannes" uniqKey="Hain J" first="Johannes" last="Hain">Johannes Hain</name><name sortKey="Schroder, Claudia" sort="Schroder, Claudia" uniqKey="Schroder C" first="Claudia" last="Schröder">Claudia Schröder</name><name sortKey="Schroder, Claudia" sort="Schroder, Claudia" uniqKey="Schroder C" first="Claudia" last="Schröder">Claudia Schröder</name><name sortKey="Wahle, Klaus" sort="Wahle, Klaus" uniqKey="Wahle K" first="Klaus" last="Wahle">Klaus Wahle</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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